High Multidrug-resistance in Urinary Tract Infections in a Tertiary Hospital, Kathmandu, Nepal

<b>This dataset is used in the following research paper. </b><b><br></b><b>ABSTRACT</b> <b>Setting</b> Tribhuvan University Teaching Tertiary Care Hospital, Kathmandu, Nepal, May-October 2019. <b>Objective</b> Among adult urine samples undergoing culture and drug sensitivity test to 1)describe the bacteriological profile, 2) identify the antimicrobial resistance (AMR) pattern and 3) find the demographic characteristics associated with the presence of bacterial growth and multidrug-resistance (MDR). <b>Design</b> A hospital based cross-sectional study using routine laboratory records.<b></b> <b>Results</b> Among 11,776 urine samples, 16% were culture-positive, predominantly caused by <i>E. coli</i> (62%)<i>. </i>We found high prevalence of resistance to at least one antibiotic (84%) and MDR (54%). Resistance to commonly used antibiotics for UTIs such as ceftazidime, levofloxacin, cefepime and ampicillin was high. Patients ≥60 years of age were more likely to have culture positivity (aPR-1.6, 95% CI-1.4-1.7).Patients with age≥45 years (45-59 years: aPR-1.5, 95% CI-1.3-1.7; ≥60 years: aPR-1.4, 95% CI-1.2-1.6), male sex (aPR-1.3, 95% CI-1.2-1.5) and from inpatient setting (aPR-1.4, 95% CI-1.2-1.7) had significantly higher prevalence of MDR. <b>Conclusion</b> Urine samples from a tertiary hospital showed high prevalence of <i>E. coli</i> and MDR resistance to routinely used antibiotics especially among inpatients. Regular surveillance and application of updated antibiograms are crucial to monitor the AMR situation in Nepal.<br><br>