Mesenteric Adipose-Derived Exosomal TINAGL1 Enhances Intestinal Fibrosis in Crohn's Disease via SMAD4

Intestinal fibrosis, a severe complication in Crohn's Disease (CD), significantly impairs patient quality of life and lacks clear molecular understanding. Emerging evidence suggests a crucial role for mesenteric adipose tissue (MAT) in CD pathophysiology, particularly through its exosome secretion, which may modulate fibrogenic pathways. This study focuses on elucidating the role of MAT-derived exosomes in CD-related fibrosis, emphasizing their molecular composition and potential impact on disease progression.