Pathogenicity of the Recombinant H5N1 Influenza Viruses in Ferrets.
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aMean fold-change in IC50 compared to that of WT virus.
bDetermined by the Kaplan-Meier method (Mantel-Haenszel test).
cDetermined once daily for 14 days of observation based on the scoring system described in Methods and was calculated as the mean score per group of ferrets per observation (day) over the 14-day period. The relative inactivity index before inoculation was 0.
dHemagglutination inhibition (HI) titers determined in ferret sera 21 days p.i. with A/Turkey/15/06 (H5N1) virus. Data are from groups of 2 (for E119A and N294S viruses) or 3 ferrets.
*P<0.05 compared to WT virus (one-way ANOVA).
创建时间：
2010-05-27
