Data from: Brain states govern the spatio-temporal dynamics of resting-state functional connectivity

Previously, using simultaneous resting-state functional magnetic resonance
imaging (fMRI) and photometry-based neuronal calcium recordings in the
anesthetized rat, we identified blood oxygenation level-dependent (BOLD)
responses directly related to slow calcium waves, revealing a cortex-wide
and spatially organized correlate of locally recorded neuronal activity
(Schwalm et al., 2017). Here, using the same techniques, we investigate
two distinct cortical activity states: persistent activity, in which
compartmentalized network dynamics were observed; and slow wave activity,
dominated by a cortex-wide BOLD component, suggesting a strong functional
coupling of inter-cortical activity. During slow wave activity we find a
correlation between the occurring slow wave events and the strength of
functional connectivity between different cortical areas. These findings
suggest that down-up transitions of neuronal excitability can drive
cortex-wide functional connectivity. This study provides further evidence
that changes in functional connectivity are dependent on the brain’s
current state, directly linked to the generation of slow waves.