Mre11 suppresses replication stress and gene amplification proficiency

ChEBI2015-03-05 更新2026-07-21 收录

DNA损伤修复

基因组稳定性

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https://www.ebi.ac.uk/biostudies/ArrayExpress/studies/E-GEOD-59487 数据链接链接失效反馈

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Mre11 suppresses replication stress and gene amplification proficiency

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2015-03-05

Discovery of Isaindigotone Derivatives as Novel Bloom’s Syndrome Protein (BLM) Helicase Inhibitors That Disrupt the BLM/DNA Interactions and Regulate the Homologous Recombination Repair

DNA损伤修复

抗癌药物设计

Homologous recombination repair (HRR), a crucial approach in DNA damage repair, is an attractive target in cancer therapy and drug design. The Bloom syndrome protein (BLM) is a 3′–5′ DNA helicase that

NIAID Data Ecosystem40

Additional file 3 of LAP2α preserves genome integrity through assisting RPA deposition on damaged chromatin

蛋白质质谱分析

DNA损伤修复

Additional file 3: Table S2. Mass spectrometry analysis of LAP2α-containing protein complexes.

Figshare2024-02-20 更新20

DNA lesions can frequently precede DNA:RNA hybrid accumulation [RNA-seq]

DNA损伤修复

DNA:RNA杂交体

While DNA:RNA hybrids contribute to multiple genomic transactions, their unscheduled formation is a recognized source of DNA lesions. Here, through a suite of systematic screens, we rather observed th

NIAID Data Ecosystem10

Supplementary Table S2 from Hyper-Dependence on NHEJ Enables Synergy between DNA-PK Inhibitors and Low-Dose Doxorubicin in Leiomyosarcoma

肿瘤基因组学

DNA损伤修复

Supplementary Table S2: Sig3 scores and FGA values in LMS tumor samples. Sig3+ samples are predicted with a classifier trained in WGS LMS data. FGA values are calculated on CNVkit-based copy number pr

Figshare2023-12-15 更新30

p38-MK2 regulate RNA metabolism after UV light-induced DNA damage

DNA损伤修复

转录调控

Ultraviolet (UV) light induces the formation of bulky UV photoproducts in the genome that interfere with DNA replication and transcription. It is well-established how human cells repair UV light-induc

NIAID Data Ecosystem20

Mre11 suppresses replication stress and gene amplification proficiency

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