The tertiary C797S mutation in the EGFR tyrosine kinase domain disrupts osimertinib binding, driving resistance in NSCLC. We designed a series of novel diaminopyrimidine derivatives to establish the i
Global Oncology Based In-vivo CRO Market Report 2024 comes with the extensive industry analysis of development components, patterns, flows and sizes. The report also calculates present and past market
Three new diterpenes, stellejasmins A (1) and B (2) and 12-O-benzoylphorbol-13-heptanoate (3), were isolated from the roots of Stellera chamaejasme L. The structures of 1–3 were elucidated by extensiv
Despite the clinical success of tropomyosin receptor kinases (TRKs) inhibitors in NTRK fusion–positive cancers, prolonged administration has resulted in acquired resistance, particularly xDFG mutation
