Expression data for hiPSC-derived RPE treated with 10mM Nicotinamide or vehicle. Homo sapiens

Nicotinamide (NAM) inhibited the expression of Age related macular degeneration (AMD) associated proteins in hiPSC-derived retinal pigment epithelium (RPE). We did the microarray analysis to examine the global impact of NAM on hiPSC-derived RPE transcriptome in order to better understand the mechanism of action of NAM. Overall design: Three hiPSC-RPE lines that had been cultured with 10mM NAM or vehicle for three weeks were used for RNA extraction and hybridization on affymetrix microarrays. We treated 2 AMD hiPSC-RPE and 1 Control hiPSC-RPE line with 10mM NAM or vehicle.