Anti-aging mechanism and effect of treatment with raw and wined Polygonatum sibiricumon D-galactose-induced aging in mice by inhibiting oxidative stress and modulating gut microbiota

The in vivo antioxidant activity of raw Rhizoma Polygonati Odorati and Rhizoma Polygonati Odorati was evaluated in a D-gal-induced senescence mouse model by measuring the antioxidant activity of serum and brain tissues of mice.Keap1/Nrf2/ARE signaling pathway, as an important pathway involved in the regulation of oxidative stress, has been shown to be involved in a number of pathological activities in the body.