The plasma proteome in ANCA-associated vasculitis

ANCA-associated vasculitides (AAV) are rare but severe disorders. Little is known about the pathophysiology of AAV. In this study, we analyzed the relative levels of 181 proteins using proximity extension assay (Olink) in plasma samples from patients with active AAV (n=66), matched population controls (n=138) and disease controls with rheumatoid arthritis (n=31) and systemic lupus erythematosus n=14), respectively. Distinct sets of upregulated proteins were identified in subgroups of patients with AAV defined by ANCA (PR3-ANCA and MPO-ANCA, respectively) compared with controls.