Small molecule binding data for protein Vascular endothelial growth factor receptor 1 and Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2), Uniprot L7RSL3
Kinases activity was assayed by ELISA. Concentrations that cause 50% inhibition (IC50) are shown as mean±SD of three to six separate experiments performed in duplicate. EGFR, epidermal growth factor r
Small molecules represent powerful tools to dissect physiological and pathological states of signaling pathways, yet require characterization through X-ray crystallography. This...
