Early Life Stress Restricts Translational Reactivity in CA3 Neurons Associated with Altered Stress Response in Adulthood. Early Life Stress Restricts Translational Reactivity in CA3 Neurons Associated with Altered Stress Response in Adulthood

Using a protocol of chronic early-life stress (ELS) induced by limited bedding and nesting material followed by acute-swim stress (AS) in adulthood, we show that mice with a history of ELS display a blunted CORT response to AS, altered levels of the repressive histone marker H3K9me3 in several hippocampal regions, and a restricted translational response to stress in CA3 neurons Overall design: Examination of the HPA, genetic, and epigenetic effects of AS in the hippocampus of control mice and mice subjected to ELS ELS = Early Life Stress, AS/FST = Acute Stress, Forced Swim Test