PFG controls gene expression in female gametocytes cooperatively with AP2-FG [PFG_ChIP-seq]

AP2-FG is a female-specific transcription factor (TF) that plays an essential role in female gametocyte development. AP2-FG activates hundreds of genes by binding to a female-specific ten-base cis-acting element. Here, we report that in the rodent malaria parasite Plasmodium berghei, another female-specific TF designated as a partner of AP2-FG (PFG), controls gene expression in female gametocytes cooperatively with AP2-FG. Transcriptional mechanisms were analyzed in Plasmodium berghei female gametocytes. Overall design: PFG_ChIP-seq, PFG_ChIP-seq in AP2-FG(-), AP2-FG_ChIP-seq in PFG(-)