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α‑Arylation of Saturated Azacycles and <i>N</i>‑Methylamines via Palladium(II)-Catalyzed C(sp<sup>3</sup>)–H Coupling

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NIAID Data Ecosystem2026-03-09 收录
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Pd­(II)-catalyzed α-C­(sp3)–H arylation of pyrrolidines, piperidines, azepanes, and N-methylamines with arylboronic acids has been developed for the first time. This transformation is applicable to wide arrays of pyrrolidines and boronic acids, including heteroaromatic boronic acids. A diastereoselective one-pot heterodiarylation of pyrrolidines has also been achieved.

创建时间:
2016-02-13
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