Parameter ranges for HT-29/B6 and IPEC-J2 cell-appropriate training data.

Δ values denote fixed step sizes used for the generation of model impedance spectra; in all other cases, step sizes were chosen dynamically in order to yield 10 steps per parameter. Values in italics denote absolute interval constraints rather than variables with varied values. Ranges for HT-29/B6 circuit parameters were based on published estimates: Rtrans between 380 and 1500 Ω·cm2, Rpara between 1500 and 4 000 Ω·cm2 which was reduced to between 20 and 100 Ω·cm2 at low [Ca2+]o, Cepi between 2.1 and 3.5 µF/cm2, Rsub (resistance of filter supports) between 2 and 10 Ω·cm2[5], [24], [25]. IPEC-J2 cells possess very high Repi (several k Ω·cm2, [47]). Literature values for any further parameter values were not available.