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Crystal structure of Plasmodium falciparum dihydroorotate dehydrogenase bound with Inhibitor DSM265

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Protein Data Bank Japan2023-09-20 更新2026-03-21 收录
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Crystal structure of Plasmodium falciparum dihydroorotate dehydrogenase bound with Inhibitor DSM265 Descriptor: 2-(1,1-difluoroethyl)-5-methyl-N-[4-(pentafluoro-lambda~6~-sulfanyl)phenyl][1,2,4]triazolo[1,5-a]pyrimidin-7-amine, Dihydroorotate dehydrogenase (quinone), mitochondrial, ... Authors: Deng, X, Phillips, M, Tomchick, D. Deposit date: 2014-12-08 Release date: 2015-07-29 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (2.25 Å) Cite: A long-duration dihydroorotate dehydrogenase inhibitor (DSM265) for prevention and treatment of malaria. Sci Transl Med, 7, 2015
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2014-12-08
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