Sex and mutation specific p53 gain-of-function activity in gliomagenesis

NIAID Data Ecosystem2026-03-13 收录

胶质瘤机制

功能获得性突变

数据链接：

https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE188710 数据链接链接失效反馈

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资源简介：

This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

创建时间：

2022-02-15

Classification of a frameshift/extended and a stop mutation in WT1 as gain of function mutations which activate cell cycle genes and promote Wilms tumor cell proliferation. Homo sapiens

Wilms肿瘤

功能获得性突变

The Wilms tumor 1 (WT1) gene encodes a zinc finger transcription factor important for normal kidney development. WT1 is a suppressor for Wilms tumor development and an oncogene for diverse malignant t

NIAID Data Ecosystem70

Prevalent p53 gain-of-function mutants co-opt epigenetic pathways to drive cancer growth

癌症表观遗传学

功能获得性突变

We investigated the genomewide binding pattern of prevalent p53 gain-of-function (GOF) mutants by ChIP-seq, in a panel of breast cancer cell lines. We assessed the genomewide changes of H3K4me3 upon G

NIAID Data Ecosystem30

PDR1 clinical isolates and location of gain-of-function mutation used in this study.

微生物抗药性

功能获得性突变

PDR1 clinical isolates and location of gain-of-function mutation used in this study.

Figshare2019-08-19 更新20

Gene expression profile of EBF1-wt & EBF1-H240A

转录因子功能研究

功能获得性突变

To study the function of EBF1-H240 residue, a gain-of function microarray analysis was performed by transducing Empty, Ebf1-wt and Ebf1-H240A expressing vectors into Ebf1-/- progenitor cells. Freshly

NIAID Data Ecosystem40

Mutant p53 R270H induces invasion and metastasis of mouse intestinal tumor organoids through gain-of-function mechanism

肠道肿瘤类器官转录组

功能获得性突变

Apc(D716) mutant mice develop benign intestinal adenoma, while Apc(D716) and p53 R270H compound mutant mice develop invasive adenocarcinoma in the intestine. We examined expression profile of tumor-d

NIAID Data Ecosystem30

Sex and mutation specific p53 gain-of-function activity in gliomagenesis

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