Complex interactions of stress-associated regulons in an mprAB deletion mutant of Mycobacterium tuberculosis. Mycobacterium tuberculosis

Using a deletion mutant lacking portions of the response regulator, MprA, and the histidine kinase, MprB, we demonstrated by DNA microarrays that MprAB activates sigE and sigB under SDS stress and during logarithmic growth. Keywords: effects of 0.05% SDS on Mtb gene expression Overall design: The expression of SigE-regulated genes {Manganelli, 2004 #212} was evaluated in SDS-treated and control cultures of H37Rv and Rv-D981, using array analyses, for each pair of samples in each experiment, dye flips were performed