Autophagy maintains metabolism and functional activity of a subset of aged hematopoietic stem cells [ERRBS]
收藏干细胞与再生医学数据中心2022-02-20 更新2024-03-06 收录
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资源简介：
Autophagy is critical for protecting HSCs from metabolic stress. Here, we used a genetic approach to inactivate autophagy in adult HSCs by deleting the Atg12 gene. We show that loss of autophagy causes accumulation of mitochondria and an oxidative phosphorylation (OXPHOS)-activated metabolic state, which drives accelerated myeloid differentiation likely through epigenetic deregulations rather than transcriptional changes, and impairs HSC self-renewal activity and regenerative potential.
提供机构：
The Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research, University of California San Francisco
创建时间：
2022-02-20
