Semi-quantitative assessment of vascular abnormalities in intact control (I−R) and irradiated (I+R) mice estimated by a board certified veterinary clinical pathologist (LS) according to standard protocols.

Numerical scale: 0 not present, +1 mild, +2 moderate, +3 marked, +4 severe. Radiation caused moderate to marked sinusoidal dilation and venous congestion on days 3 and 8 that was mostly resolved by Day 30, and transient edema on Day 8. Wilcoxon rank-sum test:*Irradiated (marginally) significantly greater sinusoidal dilation compared with control of the same day, Day 3, p = 0.0507; Day 8, p = 0.0182.†Irradiated significantly greater vascular congestion compared with control of the same day, Day3, p = 0.0247; Day8, p = 0.0217.‡Irradiated marginally significantly greater edema compared with control of the same day, Day 8, p = 0.0507.