Synthesis of 1,2-Fluorinated Ferrocenes and 1,3-Fluorinated Ferrocenes

Since the discovery of ferroquine and ferrocifen, the incorporation of ferrocene into existing biologically relevant scaffolds has been shown to be an efficient method to unveil new drug candidates with additional modes of action. Concomitantly, it is well-documented that the insertion of a fluorine atom into drugs can help fine-tune their pharmaceutical properties. However, the intersection of both methods remains rather underexplored. In this work, we designed and synthesized the corresponding 1,2-fluorinated ferrocenes and 1,3-fluorinated ferrocenes that could serve as building blocks for drug-like scaffold construction.