Transcriptomic profiling of head and neck squamous cell carcinoma cell lines. Transcriptomic profiling of head and neck squamous cell carcinoma cell lines

Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer world wide, and survival rates range from 40-80% depending on subsite. As novel treatment strategies are investigated, comprehensively characterized cell lines representative of the diversity seen in patients will be crucial to correlating genetic and phenotypic features with therapeutic response. The University of Michigan has generated a large panel of HNSCC cell lines that are utilized in laboratories worldwide. Here, we provide transcriptome sequencing of 36 of these cell lines in addition to 5 HNSCC lines derived elsewhere to inform selection of model systems for future studies. Overall design: Analysis of 41 HNSCC cell lines by 75 nucleotide paired end sequencing to >100x depth on an Illumina HiSEQ4000.