HIGHLY DIVERSE TCRalpha CHAIN REPERTOIRE OF PRE-IMMUNE CD8+ T CELLS REVEALS NEW INSIGHTS IN GENE RECOMBINATION
收藏DataCite Commons2020-10-10 更新2025-04-09 收录
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https://db.cngb.org/search/project/PRJNA152469/
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资源简介：
By sequencing tens of millions of TCRa chain transcripts from naïve mouse CD8+ T cells, we observed a hugely diverse repertoire, comprising nearly all possible TRAV-TRAJ combinations. Our findings are not compatible with sequential coordinate gene recombination, but rather with a model in which contraction and DNA looping in the TCRad locus provide equal access to TRAV and TRAJ gene segments, similar to that demonstrated for IgH gene recombination Overall design: High-throughput sequencing of entire TCRa repertoire from C57Bl/6 mice
提供机构：
CNGB
创建时间：
2018-10-20
