Trypanosoma cruzi starvation-driven mitochondrial RNA editing and transcriptome variability

This study defined differences in RNA editing among two strains (CL Brener and Sylvio X/10) and established the mechanism whereby abundances of edited (and, thus, translatable) mitochondrial gene products increase during starvation. Our approach utilized our custom T-Aligner toolkit to describe transcriptome-wide editing events and reconstruct editing products from high-throughput sequencing data.