Alpha 6 beta 4 integrin signaling pathway
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Integrins are cell surface heterodimeric protein complex consisting of one alpha and one beta chain. Integrins act as cell adhesion molecules as well as participate in cellular signaling. The ligands of the alpha6 beta4 integrin are heterotrimers belonging to the laminin family including Laminin A2, Laminin B1, Laminin C1, Laminin A3, Laminin B3, Laminin C2, Laminin A5, Laminin A1 and Laminin B2 among others. Upon activation, the receptor is phosphorylated and associates with adaptor molecules Shc and Grb2, which then activate the PI 3-kinase/Akt, MAPK/NFkB and SMAD signaling modules. Source: NetPath http://www.netpath.org/pathways?path_id=NetPath_1
整合素是一种由单一α链和单一β链组成的细胞表面异源二聚蛋白复合物。整合素不仅作为细胞粘附分子发挥作用，而且还参与细胞信号传导。α6β4整合素配体属于层粘连蛋白家族的异源三聚体，包括层粘连蛋白A2、层粘连蛋白B1、层粘连蛋白C1、层粘连蛋白A3、层粘连蛋白B3、层粘连蛋白C2、层粘连蛋白A5、层粘连蛋白A1以及层粘连蛋白B2等。在激活过程中，受体发生磷酸化并与适配分子Shc和Grb2结合，随后激活PI 3-激酶/Akt、MAPK/NFkB和SMAD信号模块。来源：NetPath http://www.netpath.org/pathways?path_id=NetPath_1
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