KazumichiOta/elderly-brain-template: Elderly Brain Template v1.0

Elderly Brain Template — Supplementary Data Repository This repository accompanies the manuscript Developing and Validating an Elderly Brain Template:A Comprehensive Comparison with MNI152 for Age-Specific Neuroimaging Analyses and provides all supplementary data, masks and metrics required to reproduce the figures and statistics in the paper. 1. Overview Template construction– 90 OASIS-1 scans (65–84 y) Template validation– 282 IXI scans (QC-passed; 20–80 y) Age range addressed– older adults, 65 years and above Content highlights Final 1 mm isotropic T1 template Brain, tissue-class and 7 subcortical masks CSV tables with Dice and whole-brain metrics (3D-SSIM, CC, MSE) Convergence log of 20 iterative template-building updates 2. File Contents | Path | Description | |-----|-------------| | tpl-Elderly_res-01_T1w.nii.gz | 1 mm T1-weighted elderly template (176 × 208 × 176, RAS) | | desc-brain_mask.nii.gz | Intracranial brain mask | | gm_mask.nii.gz / wm_mask.nii.gz / csf_mask.nii.gz | Tissue-class probability masks generated with SynthSeg | | atlas-Subcortex7_dseg.nii.gz | 7 binary masks: amygdala, caudate, hippocampus, pallidum, putamen, thalamus, brainstem | | IXI_region_dice.csv | Dice coefficients for each ROI × template × subject | | IXI_metrics.csv | Whole-brain 3D-SSIM, CC, MSE for each subject | | template_construction_metrics.csv | 20-step convergence metrics (phase, CC, MSE, 3D-SSIM) | | Oasis_Japan_demographics.csv | Age / sex table for the 90 OASIS-1 subjects | All masks are provided under `masks/`.```textmasks/├─ subcortical/ # 7 binary ROI masks│ ├─ brainstem_mask.nii.gz│ ├─ amygdala_mask.nii.gz│ ├─ caudate_mask.nii.gz│ ├─ hippocampus_mask.nii.gz│ ├─ pallidum_mask.nii.gz│ ├─ putamen_mask.nii.gz│ └─ thalamus_mask.nii.gz└─ tissue/ # tissue-class masks (SynthSeg) ├─ gm_mask.nii.gz ├─ wm_mask.nii.gz └─ csf_mask.nii.gz``` 3. Usage Download the NIfTI template and masks from the release assets or Zenodo (DOI below). Register your subject images to tpl-Elderly_res-01_T1w.nii.gz using ANTs or your preferred tool. Compute overlap or similarity metrics by loading the CSV templates or running the supplied scripts (see /scripts). Age-group note: the Age_Group column in the CSV files (A = 20-29 … F = ≥ 70) is only for visual grouping; all statistical models in the paper treat age as continuous. 4. License All files are released under Creative Commons Attribution-ShareAlike 4.0 (CC BY-SA 4.0).Because the template derives from IXI (CC BY-SA 3.0) and OASIS-1 (OASIS DUA) MRI data, users must also respect those original licences and DUAs. 5. Citation If you use this template or any associated data, please cite **both** the article and the dataset: Ota K (Corresponding author), Nakazato Y., Oyama G.Developing and Validating an Elderly Brain Template:A Comprehensive Comparison with MNI152 for Age-Specific Neuroimaging Analyses.NeuroImage. 2025; 320:121473. https://doi.org/10.1016/j.neuroimage.2025.121473 Dataset (concept DOI; latest): https://doi.org/10.5281/zenodo.16249928 Dataset DOI https://doi.org/10.5281/zenodo.16249929 (Elderly Brain Template v1.0) 6. Contact Corresponding authorKazumichi Ota, M.D., Ph.D.Department of Neurology, Saitama Medical UniversityE-mail: [e-mail] 7. Acknowledgements We acknowledge the open-access IXI and OASIS projects for providing the foundational MRI datasets that enabled this work. No dedicated external funding was received.