Crystal structure of Lp-PLA2 in complex with a novel covalent inhibitor.
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Crystal structure of Lp-PLA2 in complex with a novel covalent inhibitor. Descriptor: (2S)-2-[(Z)-3-[2-(diethylamino)ethyl-[[4-[4-(trifluoromethyl)phenyl]phenyl]methyl]amino]-1-oxidanyl-3-oxidanylidene-prop-1-enyl]pyrrolidine-1-carboxylic acid, Platelet-activating factor acetylhydrolase Authors: Hu, H.C, Xu, Y.C. Deposit date: 2020-02-20 Release date: 2020-12-30 Last modified: 2024-11-20 Method: X-RAY DIFFRACTION (2.19 Å) Cite: Identification of Highly Selective Lipoprotein-Associated Phospholipase A2 (Lp-PLA2) Inhibitors by a Covalent Fragment-Based Approach. J.Med.Chem., 63, 2020
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2020-02-20
