ERG-mediated coregulator complex formation maintains androgen receptor signaling in prostate cancer [ERG ChIP]
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https://www.ncbi.nlm.nih.gov/sra/SRP279947
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资源简介：
We report the effects of ERG on prostate tumorigenesis, ERG-mediated oncogene addiction, and downstream AR signaling pathways. We determined that ERG facilitates AR-signaling and mediates transformation of prostate cells by maintaining coregulator complex formation at AR-bound sites across the genome. Overall design: We measured changes in multiple chromatin, transcription factor binding, and transcriptomic profiles from genetic alterations of Pten and ERG murine prostate organoids
创建时间：
2020-12-05
