Asymmetric Bromolactonization Using Amino-thiocarbamate Catalyst
收藏NIAID Data Ecosystem2026-03-06 收录
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A novel amino-thiocarbamate-catalyzed bromolactonization of unsaturated carboxylic acids has been developed. The scope of the reaction is evidenced by 22 examples of γ-lactones with up to 99% yield and 93% ee. The protocol was applied in the enantioselective synthesis of the key intermediates of VLA-4 antagonists.
创建时间：
2010-11-10
