IMPACTS OF ALTERATIONS OF LEVEL OF GLYCOSYLATED HEMOGLOBIN IN DIABETICS ACCORDING TO PRESENCE OF CORONARY HEART DISEASE AND HYPERTENSION

Objective: To examine the clinical impact of the alterations in the levels of glycosylated hemoglobin of diabetics on the Chronic Heart Disease and Hypertension. Methodology: Division of total 196 patients carried out in two groups; control group comprising 96 patients without diabetes and patient group with 100 diabetics. The comparison of the biochemical indexes of the patients of both groups was carried out. Moreover, the division of the patients of the observation group was carried out in different sub-groups in accordance with the availability of hypertension and chronic heart disease and the comparison of the HbA1c level was carried out in various sub-groups. Results: There was no significant difference in the levels of TC (Total Cholesterol), TG (Triglyceride) and LDL-C (Low-Density Lipoprotein Cholesterol) of the patients in both groups (P>0.050). However, level of HDL-C (High Density Lipoprotein-Cholesterol) of the patients in observational group was much low as compared to the subjects of control group (P Conclusion: HbA1c level of the patients suffering from diabetes was in a strong association with the blood pressure and CRP level. HbA1c level can predict the rate of occurrence of hypertension and chronic heart disease. Identification of the values of glycosylated hemoglobin is much vital in the screening of the patients present with hypertension and chronic heart disease. KEY WORDS: Diabetics, Blood Pressure, Hba1c, Hypertension, Chronic Heart Disease, Systolic, Diastolic, Plasma, Fasting Plasma Glucose.