An ATP “Synthase” Derived from a Single Structural Domain ofBacterial Histidine Kinase
收藏中国科学院兰州化学物理研究所科学数据中心2026-01-16 更新2026-01-17 收录
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ATP (adenosine triphosphate) is a vital energysource for living organisms, and its biosynthesis andprecise concentration regulation often depend on macromolecular machinery composed of protein complexesor complicated multidomain proteins. We have identified a single-domain protein HK853CA derived frombacterial histidine kinases (HK) that can catalyze ATPsynthesis efficiently. Here, we explored the reactionmechanism and multiple factors that influence thiscatalysis through a combination of experimental techniques and molecular simulations. Moreover, we optimized its enzymatic activity and applied it as an ATPreplenishment machinery to other ATP-dependent systems. Our results broaden the understanding of ATPbiosynthesis and show that the single CA domain can beapplied as a new biomolecular catalyst used for ATPsupply.
提供机构：
中国科学院兰州化学物理研究所科学数据中心
创建时间：
2026-01-16
