STDP at CA3-CA1 synapses with single pre- and post-synaptic spikes (the doublet protocol).

(A) Data reproduced from [19], fit with a Gaussian function (least squares fit). The grey dots indicate an inter-pairing frequency of 0.1 Hz and 0.5 Hz. The black dots indicate an inter-pairing frequency of 5 Hz. refers to the time between the pre-synaptic spike and the post-synaptic spike. refers to the change in synaptic strength relative to initial strength. (B) The model produced latency-dependent LTD-only curves (0.5 Hz grey, 5 Hz black). The curves are nearly indistinguishable. (C) Mean value of the dynamic time constant for each value of in panel B. The doublet protocol has little effect on . Curves correspond to those in panel B.