Examples of endoxifen sensitivity associated gene/miRNA expression identified in YRI and replicated in CEU LCLs.

p-S1, p-S2, p-S3, p-S4, p-S5 and p-S6 are short for p-values of each step, from step 1 to step 6. Step 1, the association between the phenotypes of endoxifen sensitivity and ∼13,000 gene/transcript cluster expressions; step 2, the association between the phenotypes of endoxifen sensitivity and 201 miRNA expressions; step 3, the negative correlation between mRNA and miRNA expressions from step 1 and step 2; step 4, the association between mRNA expressions from step 3 and SNP genotypes; step 5, the association between miRNA expression from step 3 and SNP genotypes from step 4; step 6, the association of SNP genotypes from step 5 and the phenotypes of endoxifen sensitivity. NS, not significant at p<0.05 threshold.