Search results of kinetic parameter space and prediction of MdmX effect.

aSearches converged to a kinetic parameter set with fitness score ≥0.25 were considered as a succeeded trial. bThe presence of MdmX (upto 100 fold k15) increased dependency by >5% increase (low Mdm2) and >5% decrease (high Mdm2) of mRNA levels (species 15). cThe presence of MdmX (upto 100 fold k15) decreased maximum value (peak of oscillations) by >30%. dThe decrease of maximum value (peak of oscillations) was below 5% in the presenece of MdmX (upto 100 fold k15).