Phosphoproteomics reveals key regulatory kinases and modulated pathways involved in tumorigenesis of ovarian cancer

The present study comprehensively revealed the molecular characteristics in relation to OC and identified significantly distinct phosphorylated sites and phosphorylated proteins underlying the syndrome. The results here dissected regulatory elements (especially kinases) and pathways involved in cancer-related pathways including fructose & mannose metabolism, MAPK, ErbB, and ErbB signaling pathway. These findings may not only provide potential biomarkers and novel therapeutic targets for OC, but also bolstered our knowledge on the physiopathology of this syndrome.