Cervicovaginal microbiome study on the susceptibility to ascension of C. trachomatis using 16S rRNA sequencing data

Chlamydial infection, sexually transmitted by a bacterial pathogen called Chlamydia trachomatis, can lead to severe conditions like pelvic inflammatory disease or infertility if the bacteria ascends to the upper genital tract. Studies on the cervicovaginal microbiome have shown that the composition of the vaginal microbiota may be associated with chlamydial infection through modulating host immune responses. We aim to identify vaginal microbial biomarkers which are predictive of susceptibility to the ascension of Chlamydia trachomatis.