Genome-wide analysis of the JAM-C over-expressed trophoblasts. Genome-wide analysis of the JAM-C over-expressed trophoblasts

During pregnancy, trophoblasts in the placenta are important in the success of pregnancy. We identify an adhesion molucule, JAM-C, which expresses on membrane of column cytotrophoblasts and regulates the differentiation and migration of trophoblasts. Primary cytotrophoblasts isolated from 1st trimester villi were transfected with JAM-C or control plasmids. RNA-seq analysis was sujected to identify differentially expressed genes and pathways potentially altered. Overall design: Overall 6 samples: 2 cell types from 3 donors