Incremental prognostic role of left atrial reservoir strain in asymptomatic patients with moderate aortic stenosis

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Abstract
Left atrial (LA) mechanics assessed by two-dimensional speckle tracking echocardiography (2D-STE) have not been extensively
studied and clearly characterized in patients with moderate aortic stenosis (AS). Accordingly, we aimed to evaluate
the usefulness of LA reservoir strain for risk stratification of asymptomatic patients with moderate AS. This retrospective
study included all consecutive asymptomatic patients with moderate AS who underwent transthoracic echocardiography
implemented with 2D-STE analysis of LA myocardial strain and strain rate indices at our Institution, between February 2011
and September 2019. During the follow-up period, we evaluated the occurrence of any of the following: (1) CV hospitalization;
(2) The recourse to AS surgery; (3) Cardiac death or sudden death. A total of 186 patients (mean age 71.9 ± 12.7 years,
61.8% men) were included in the present study. During a mean follow-up of 2.3 ± 1.9 years, no patients died and 63 adverse
CV events were recorded: 48 patients were hospitalized because of heart failure (28 patients), acute coronary syndrome (10
patients), arrhythmias (10 patients) and 15 patients underwent AS surgery. At the multivariate Cox regression analysis, type 2
diabetes mellitus (OR 1.87, 95%CI 1.05–3.34, p = 0.03), NT-proBNP (OR average 1.14, 95%CI 1.02–1.27, p = 0.02), average
E/e′ ratio (OR 1.07, 95%CI 1.01–1.15, p = 0.04) and most of all left atrial positive global strain (LA-GSA+) (OR 0.85, 95%CI
0.81–0.90, p < 0.0001) were independently associated with the outcome. LA-GSA+ (optimal cut-off ≤ 19%, AUC = 0.94,
87% sensitivity, 99% specificity, positive predictive value 99%, negative predictive value 88%) showed the highest diagnostic
performance. An impaired LA reservoir strain can contribute to identify a subset of asymptomatic patients with moderate
AS at higher risk, who may benefit from closer echocardiographic follow-up and/or early surgery.