Change in VW-MTR in NABT over time – comparison between patients and HCs with increasing and decreasing VW-MTR (mm3).

aFailed analysis or missing MRI at Week 24.bFor the difference from zero within groups from the Wilcoxon signed–rank test.cAdjusted for multiple comparisons with the Holm-Bonferroni correction.dFor the difference between IFN β-1a SC and HC from the Wilcoxon rank–sum test.eFor the difference between the first 12 weeks and the second 12 weeks within groups from the Wilcoxon signed–rank test (p-value for patients/HCs).HC, healthy control; IFN β-1a, interferon beta-1a; NABT, normal appearing brain tissue; Max, maximum; Min, minimum; NS, non-significant; SC, subcutaneously; SD, standard deviation; VW-MTR, voxel-wise magnetic transfer ratio.