Data Sheet 1_Prevalence of on time administration of carbapenem and its impact on PK/PD target attainment in hospitalized patients: a multicenter retrospective study.docx

ObjectiveOn time administration of carbapenem is important, but there are few data concerning the prevalence of timeliness and its impact on pharmacokinetic/pharmacodynamic (PK/PD) target achievement in hospitalized patients.
MethodsThis was a multicenter retrospective study. Inpatients who received imipenem or meropenem for more than 3 consecutive days were included according to preset criteria. Patient information and dosing information were collected. The actual administration intervals were compared to the scheduled intervals, and those within a 1-hour error interval were defined as standard time window administration (STWA); otherwise, they were defined as noncompliant time window administration (NTWA). The 100% fT>MIC and 100% fT>4×MIC targets were applied for PK/PD target attainment analysis. A multivariable logistic regression model was used to identify independent risk factors associated with timely administration and the PK/PD target attainment rate.
ResultsA total of 474 patients and 1,372 actual administration intervals were included in this study. Among these patients, 82 had drug concentration data and were analyzed for PK/PD target attainment. A total of 427 dosing intervals (31.12%) complied with the standard time window and were STWA, whereas 945 (68.88%) were NTWA. Weekend, night shift, and scheduled dosing intervals were found to be independent influencing factors for STWA. STWA was an independent influencing factor for the 100% fT>MIC and 100% fT>4×MIC target attainment rates.
ConclusionOur results indicate a low rate of on time carbapenem administration. The on time carbapenem administration was a risk factor for PK/PD target attainment and should be well controlled in clinical practice.