Appropriate local pH value boosting the efficacy of fibroblast growth factor to promote wound repair

To explore whether the application of FGF with different isoelectric points in wounds with different pH values, GelMA hydrogels with different pH values were prepared to maintain the wounds microenvironment with the same pH values, in which aFGF and bFGF were loaded as well.interferes with the healing process to different degrees, We then performed gene expression profiling analysis using data obtained from RNA-seq of 21 mice in 7 groups.