A Dataset on Splicing Regulation in Heart Failure from Integrated Genomic and Transcriptomic Sequencing

Integrative, summary-level resource quantifying splicing regulation in human heart failure from bulk RNA‑seq of the left ventricle. We provide joint RNA‑seq germline variant calls (DeepVariant/GLnexus), VEP+SpliceAI annotations, overlaps with POSTAR3 RBP peaks, curated HF vs. non‑failing donor (NFD) group labels, and junction extraction/annotation (regtools), plus outlier splicing calls (LeafCutterMD) for a Magnet subset. Across 941 samples from 7 studies, we detect 7,981,017 variants (976,936 PASS) and 5,333 high‑confidence splice‑impact candidates (SpliceAI DS ≥ 0.8). Contact the author for more details