Statistical significance of DR-mediated changes in fecundity and lifespan of Drosophila melanogaster strains. The yeast concentration from 0.5 to 0.1 is excluded from the DR range estimation. For fecu

Figshare2015-12-02 更新30

Using Auxin-inducible-degradation System to Interrogate Tissue-specific Transcriptional Programs of HSF-1 in Lifespan Assurance [HSF-1 transcriptome in the soma]. Using Auxin-inducible-degradation System to Interrogate Tissue-specific Transcriptional Programs of HSF-1 in Lifespan Assurance [HSF-1 transcriptome in the soma]

转录组学

衰老与寿命研究

To determine the transcriptional program of HSF-1 in lifespan assurance in C. elegans, we coupled HSF-1 depletion specifically from the soma by auxin-inducible degron (AID) with RNA-seq analyses in wh

NIAID Data Ecosystem20

Dietary restriction in Caenorhabditis elegans. Caenorhabditis elegans

衰老分子机制

饮食限制干预

Dietary restriction (DR) is the most effective and reproducible intervention to extend lifespan in divergent species1. In mammals, two regimens of DR, intermittent fasting (IF) and caloric restriction

NIAID Data Ecosystem40

Chronic and later onset dietary restriction mitigate the age-associated decline in the mouse B cell receptor repertoire diversity. B cell receptor repertoire sequences

免疫衰老

饮食限制干预

Ageing impairs the capacity of the organism to respond to novel antigens. Ageing individuals experience a decline in adaptive immune function, which translates into decreased protection against pathog

NIAID Data Ecosystem20