The mean delta score (SD) (post-treatment values minus pre-treatment values) of the pressure and heat pain threshold, the pressure pain tolerance (PPTo) and the heat pain tolerance (HPTo) tests or sedation score (n = 61).

Visual analogue scale (VAS).Different superscripts (a, b, and c) indicate significant differences among treatment groups according to the Bonferroni test.†Kruskal-Wallis test with Dunn's Multiple Comparison Test to identify changes between groups.$ Mixed ANOVA model.Standardized mean difference (SMD) [(pre minus post)/baseline standard deviation]. The size effect was interpreted as follows: small, 0.20;, moderate, 0.50–0.60 and large, 0.80.