Statistically unbiased prediction enables accurate denoising of voltage imaging data

Name: Statistically unbiased prediction enables accurate denoising of voltage imaging data
Creator: Zenodo
Published: 2022-11-17T09:57:17+08:00

Zenodo2023-09-26 更新2026-05-25 收录

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https://zenodo.org/record/7330130 数据链接链接失效反馈

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资源简介：

Here we report SUPPORT (Statistically Unbiased Prediction utilizing sPatiOtempoRal information in imaging daTa), a self-supervised learning method for removing Poisson-Gaussian noise in voltage imaging data. SUPPORT is based on the insight that a pixel value in voltage imaging data is highly dependent on its spatially neighboring pixels in the same time frame, even when its temporally adjacent frames do not provide useful information for statistical prediction. Such spatiotemporal dependency is captured and utilized to accurately denoise voltage imaging data in which the existence of the action potential in a time frame cannot be inferred by the information in other frames. Through simulation and experiments, we show that SUPPORT enables precise denoising of voltage imaging data while preserving the underlying dynamics in the scene. Datasets for volumetric structural imaging of penicillium and calcium imaging of zebrafish. Volumetric structural imaging of penicillium 221110_C2_16X0p8NA_w_Pen_FITC_0p5Hz_SinglePlane_S1R1_xy0p34um_laser0p5_Gain10_pinhole2p7AU.tif --> Low SNR image 221110_C2_16X0p8NA_w_Pen_FITC_0p5Hz_SinglePlane_S1R2_xy0p34um_laser10_Gain2_pinhole2p7AU.tif --> High SNR image Calcium imaging of zebrafish 221024_C2_16X0p8NA_w_casper_GCaMP7a_4dpf_FITC_1Hz_SinglePlane_Whole_S7R1_xy0p75um_laser1_Gain10_pinhole1p8AU.tif --> Multiple regions 221024_C2_16X0p8NA_w_casper_GCaMP7a_4dpf_FITC_2Hz_SinglePlane_Ce_S7R1_xy0p34um_laser1p5_Gain10_pinhole1p8AU.tif --> Cerebellar plate 221024_C2_16X0p8NA_w_casper_GCaMP7a_4dpf_FITC_2Hz_SinglePlane_D_S7R1_xy0p34um_laser1p5_Gain10_pinhole1p8AU.tif --> Dorsal telencephalon 221024_C2_16X0p8NA_w_casper_GCaMP7a_4dpf_FITC_2Hz_SinglePlane_MO_S7R1_xy0p34um_laser1p5_Gain10_pinhole1p8AU.tif --> Medullar oblongata 221024_C2_16X0p8NA_w_casper_GCaMP7a_4dpf_FITC_2Hz_SinglePlane_OB_S7R1_xy0p34um_laser5_Gain20_pinhole1p8AU.tif --> Olfactory bulb 221024_C2_16X0p8NA_w_casper_GCaMP7a_4dpf_FITC_2Hz_SinglePlane_OT_S7R1_xy0p34um_laser1p5_Gain10_pinhole1p8AU.tif --> Optic tectum 221024_C2_16X0p8NA_w_casper_GCaMP7a_4dpf_FITC_4Hz_SinglePlane_Hb_S7R1_xy0p34um_laser1p5_Gain15_pinhole1p8AU.tif --> Habenula

提供机构：

Zenodo

创建时间：

2022-11-17

Statistically unbiased prediction enables accurate denoising of voltage imaging data

资源简介：

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