RNA-sequencing (RNAseq) based transcriptomic profiling of aortae from C57BL/6 mouse by control or 24-hr fasting

We performed RNA sequencing (RNA-Seq) based transcriptomic profiling of aortae from C57BL/6 mice by control or 24-hr fasting. Our RNA-Seq analysis revealed 529 altered genes (1.5 fold change, p<0.05), of which 278 genes were significantly up-regualted and 251 genes were significantly down-regulated in aortae isolated from mice by 24-hr fasting.Gene ontology and pathway analysis of the up-regulated genes indicated that multiple biological processes were enriched including regulation_of_cellular_metabolic_process, while the down-regulated genes were enriched in the biological processes such as sterol_biosynthetic_process. Examination of differentially expressed genes between aortae isolated from control mice and 24 hr-fasting mice