The 50% effective concentrations (EC₅₀) and inhibitory quotients (IQ) for amantadine, ribavirin, oseltamivir carboxylate, and TCAD^a against representative susceptible and resistant viruses.

EC50 values are the mean of three to five experiments (three replicates per experiment). aTCAD, triple combination antiviral drug (amantadine, ribavirin, and oseltamivir carboxylate) as a fixed-ratio combination. bTCAD was formulated as a fixed-ratio combination based on the Cave of each drug, wherein at 1-fold Cave each drug was present at the following concentration: 0.43µg/mL amantadine, 0.3 µg/mL oseltamivir carboxylate, and 1.3 µg/mL ribavirin. TCAD was then titrated keeping the ratio of the drugs constant. The EC50 of TCAD is expressed as a ratio to the Cave.