Comparison of the presence of symptoms and HRQOL at the start of pre-dialysis care and the moment of reaching an endpoint.

Symptoms are presented as frequencies (%) and the number of symptoms and HRQOL as mean (standard error of the mean).
∧Defined as starting dialysis, receiving a kidney transplant, and death.
§The onset of symptoms (%) was calculated as follows: (% endpoint - % start)/(100% - % start).
†The mean physical and mental summary scores in the general Dutch population are 76.3 and 77.9 respectively.
*p<0.05, adjusted for eGFR;
**p<0.005, adjusted for eGFR, difference between baseline and the moment of reaching an endpoint, obtained with a linear mixed model.