Influence of acetylation levels on dual-modified corn starch in colon-targeted Budesonide tablet formulation

Although starch is an affordable and safe biodegradable polymer, its rapid breakdown in the upper gastrointestinal tract renders it an unsuitable excipient for colon-targeted oral tablets. The current study examined the influence of varying degrees of acetylation on dual-modified (retrograded and acetylated) corn starch as a polymer in the formulation of colon-targeted tablets, emphasizing drug release and suitability for direct compression, utilizing Budesonide as a model drug. Starch acetylation was performed using acetic anhydride as the acetylating agent and water or acetic acid as the solvent to prepare starch with low, medium, and high degrees of substitution. Analysis techniques confirmed the presence of acetyl groups, revealed changes in crystalline structure, and illustrated morphological alterations post-acetylation. Among the various degrees of substitution (DS) studied, it was evident that starch acetylated to a high degree offered the most promising attributes as an excipie..., , , # Data from: Influence of acetylation levels on dual-modified corn starch in colon-targeted Budesonide tablet formulation

[https://doi.org/10.5061/dryad.69p8cz99n](https://doi.org/10.5061/dryad.69p8cz99n)

**Description of the data and file structure**

The dataset consists of four .xlsx files. In all of these files, four types of tablet formulation were evaluated which contain native starch (NCS) formulation F1, low substituted corn starch (LDSCS) formulation F2, medium substituted corn starch (MDSCS) formulation F3, and high degree of substitute corn starch (HDSCS) formulation F4, respectively. These files with corresponding variables are described below:

1.     File name: \"Hardness_Friabiity_DT”, which supports Table 2 (Post-compression assessment of different starch tablet formulations) in the manuscript. Variable name and description:

*a)     Hardness (3 observations)-Tablet hardness measured in Kg/cm2*

*b)     Mean Hardness- Mean of three observations of hardness expressed as ...