Structure of human Hsp90-alpha bound to purine inhibitor PU-H36

Structure of human Hsp90-alpha bound to purine inhibitor PU-H36 Descriptor: 9-(pent-4-yn-1-yl)-8-[(2,4,6-trimethylphenyl)sulfanyl]-9H-purin-6-amine, Heat shock protein HSP 90-alpha, MAGNESIUM ION Authors: Que, N.S, Gewirth, D.T. Deposit date: 2023-04-04 Release date: 2024-10-09 Last modified: 2025-02-19 Method: X-RAY DIFFRACTION (1.5 Å) Cite: Selective Inhibition of hsp90 Paralogs: Uncovering the Role of Helix 1 in Grp94-Selective Ligand Binding. Proteins, 93, 2025