We performed ChIP-seq on MV4-11 or OCI-AML3 cells which had been treated with DMSO or 5 nM of the FLT3 inhibitor Quizartinib (AC220) to determine the location of ATF4 or RNAPII across the genome. Over

NIAID Data Ecosystem60

Serine biosynthesis is a metabolic vulnerability in FLT3-ITD-driven acute myeloid leukaemia [MV411_OCI-AML3_DMSO_AC220_24hr]. Serine biosynthesis is a metabolic vulnerability in FLT3-ITD-driven acute myeloid leukaemia [MV411_OCI-AML3_DMSO_AC220_24hr]

急性髓系白血病代谢

FLT3抑制剂转录组

We performed 3'-RNA-Sequencing on RNA isolated from human MV4-11 and OCI-AML3 cells which had been treated with DMSO or the FLT3 inhibitor Quizartinib (AC220) to perform differential gene expression a

NIAID Data Ecosystem30

miRNA-1 promotes Acute Myeloid Leukemia cell pathogenesis through metabolic regulation [mRNA]. miRNA-1 promotes Acute Myeloid Leukemia cell pathogenesis through metabolic regulation [mRNA]

急性髓系白血病代谢

miRNA功能机制

Acute myeloid leukemia (AML) is a heterogeneous and deadly disease characterized by uncontrolled expansion of malignant blasts. The current treatment for AML patients includes intensive chemotherapy a

NIAID Data Ecosystem70

Raw data in metabolomic profiling and analysis

急性髓系白血病代谢

肿瘤微环境

In this study, we identify a significant induction of a CD81+ erythroblast subpopulation in the spleens of an AML mouse model, which can promote AML cell proliferation and reduce mice survival. To inv

NIAID Data Ecosystem50

The m6A Reader IGF2BP2 Regulates Glutamine Metabolism and Represents a Therapeutic Target in Acute Myeloid Leukemia

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